Author's response to reviews Title: Variation in the circle of Willis in a Sri Lankan Population Authors:
نویسندگان
چکیده
Background: The variations of the circle of Willis (CW) are clinically important as patients with efficient effective collateral circulations have a lower risk of transient ischemic attack and stroke than those with ineffective collaterals. The aim of the present cadaveric study was to investigate the anatomical variations of the CW and to compare the frequency of occurrence of the different variations with previous autopsy studies as variations in the anatomy of the CW as a whole have not been studied in the Indian subcontinent. Methods: The external diameter of all the arteries forming the CW in 225 normal Sri Lankan adult cadaver brains was measured using a calibrated grid to determine the occurrence of prevalence in the variation in CW. Pearson Brown ranked correlation (ρ) Chisquared tests and a correspondence analysis were performed to study the anatomical variations in the CW across the 6 studies of diverse ethnic populations. Results: We report 15 types of variations of CW out of 28 22 types previously described and one additional type: hypoplastic precommunicating part of the anterior cerebral arteries (A1) and contralateral posterior communicating arteries (PcoA) 5(2.2%). A global chisquared test was used to compare across all 6 studies and pairwise chisquared tests were used to test for differences between each pair of studies; all comparisons were statistically significant (p=0.0000) indicating differences among the studies. A subsequent correspondence analysis revealed a marked difference between the
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ABSTRACT Anatomical variations have great importance among various medical disciplins. The significance of these variations differ from some points of view including system, site and degree of variation. Vascular system is a common site of variations. The importance of this system in supplying the organs, specially the brain has made it to be in focus for its variations. The main sourc...
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